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Takehiko Kobayashi Selected Research

Ribosomal DNA (rDNA)

1/2021The S-Phase Cyclin Clb5 Promotes rRNA Gene (rDNA) Stability by Maintaining Replication Initiation Efficiency in rDNA.
1/2016More than 10% of yeast genes are related to genome stability and influence cellular senescence via rDNA maintenance.
2/2014Ribosomal DNA and cellular senescence: new evidence supporting the connection between rDNA and aging.
9/2013Cellular senescence in yeast is regulated by rDNA noncoding transcription.
6/2011How does genome instability affect lifespan?: roles of rDNA and telomeres.
1/2007Abnormality in initiation program of DNA replication is monitored by the highly repetitive rRNA gene array on chromosome XII in budding yeast.

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Takehiko Kobayashi Research Topics

Disease

5Lung Diseases (Lung Disease)
03/2021 - 01/2017
5Genomic Instability
01/2021 - 06/2011
3Starvation
01/2021 - 01/2018
3Neoplasms (Cancer)
01/2018 - 09/2013
2Tuberculosis (Tuberculoses)
04/2022 - 11/2018
2Pneumonia (Pneumonitis)
01/2021 - 01/2017
2Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
09/2017 - 09/2013
1Clostridium Infections
04/2022
1COVID-19
11/2021
1Cardiovascular Diseases (Cardiovascular Disease)
11/2021
1Fever (Fevers)
11/2021
1Dyspnea (Shortness of Breath)
11/2021
1Exanthema (Rash)
03/2021
1Neutropenia
03/2021
1Drug Fever
03/2021
1Liver Diseases (Liver Disease)
03/2021
1Dysgeusia (Parageusia)
03/2021
1Extrinsic Allergic Alveolitis (Hypersensitivity Pneumonitis)
01/2021
1Coinfection
01/2020
1Thrombocytopenia (Thrombopenia)
11/2018
1Pulmonary Tuberculosis
11/2018
1Diabetes Mellitus
01/2018
1Infections
01/2018
1Hypothyroidism
09/2017
1Lung Neoplasms (Lung Cancer)
09/2017
1Bacterial Infections (Bacterial Infection)
01/2017
1Cryptogenic Organizing Pneumonia
01/2017
1Herpes Simplex Encephalitis (Herpes Encephalitis)
01/2017
1Chromosomal Instability (Chromosome Stability)
05/2015
1Taste Disorders (Taste Disorder)
01/2014
1Head and Neck Neoplasms (Head and Neck Cancer)
01/2014
1Glandular and Epithelial Neoplasms (Neoplasms, Glandular)
12/2013
1Squamous Cell Carcinoma (Epidermoid Carcinoma)
12/2013
1Neoplasm Metastasis (Metastasis)
12/2013
1Thymoma (Thymic Carcinoma)
12/2013
1Thromboembolism
09/2013
1Embolism (Embolus)
09/2013
1Adenocarcinoma of Lung
09/2013
1Hemiplegia (Spastic Hemiplegia)
09/2013
1Carcinoma (Carcinomatosis)
04/2013
1Brain Neoplasms (Brain Tumor)
04/2013
1Stomach Neoplasms (Stomach Cancer)
07/2008
1Chromosome Duplication
01/2007
1Germ Cell and Embryonal Neoplasms (Germ Cell Tumor)
12/2002
1Nasopharyngeal Carcinoma
10/2002
1Squamous Cell Carcinoma of Head and Neck
02/2002
1Carcinogenesis
02/2002

Drug/Important Bio-Agent (IBA)

6Ribosomal DNA (rDNA)IBA
01/2021 - 01/2007
3Mechanistic Target of Rapamycin Complex 1IBA
01/2021 - 01/2018
3Cisplatin (Platino)FDA LinkGeneric
01/2014 - 02/2002
2Anti-Bacterial Agents (Antibiotics)IBA
03/2021 - 01/2018
2Clarithromycin (Biaxin)FDA LinkGeneric
03/2021 - 07/2020
2DNA (Deoxyribonucleic Acid)IBA
01/2021 - 05/2015
2Pharmaceutical PreparationsIBA
01/2021 - 01/2018
2Protein Kinases (Protein Kinase)IBA
01/2021 - 09/2019
2AntibodiesIBA
01/2020 - 09/2017
2Docetaxel (Taxotere)FDA Link
01/2014 - 12/2013
1Rifampin (Rifampicin)FDA LinkGeneric
04/2022
1Biomarkers (Surrogate Marker)IBA
11/2021
1Azithromycin (Zithromax)FDA LinkGeneric
03/2021
1Nuclear Proteins (Protein, Nuclear)IBA
01/2021
1Ethambutol (Myambutol)FDA LinkGeneric
07/2020
1MacrolidesIBA
07/2020
1Immunoglobulin A (IgA)IBA
01/2020
1AntigensIBA
01/2020
1SteroidsIBA
01/2018
1NivolumabIBA
09/2017
1Immune Checkpoint InhibitorsIBA
09/2017
1ThyroglobulinFDA Link
09/2017
1Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA
01/2017
1Antiviral Agents (Antivirals)IBA
01/2017
1Adrenal Cortex Hormones (Corticosteroids)IBA
01/2017
1Acetaminophen (Paracetamol)FDA LinkGeneric
01/2017
1ChromatinIBA
02/2014
1trans-crotonin (CTN)IBA
01/2014
1nedaplatinIBA
12/2013
1Histone Deacetylases (Histone Deacetylase)IBA
09/2013
1Carboplatin (JM8)FDA LinkGeneric
09/2013
1Pemetrexed (MTA)FDA Link
09/2013
1Gefitinib (Iressa)FDA Link
04/2013
1PlatinumIBA
07/2008
1Antineoplastic Agents (Antineoplastics)IBA
07/2008
1Oxaliplatin (Eloxatin)FDA LinkGeneric
07/2008
1Fas Ligand Protein (Fas Ligand)IBA
10/2002
1Methylnitrosourea (N-Methyl-N-nitrosourea)IBA
02/2002
1Caspase 9IBA
02/2002

Therapy/Procedure

6Therapeutics
03/2021 - 09/2013
5Drug Therapy (Chemotherapy)
11/2018 - 12/2002
1Immunotherapy
01/2021
1Aftercare (After-Treatment)
09/2017
1Induction Chemotherapy
01/2014
1Combination Drug Therapy (Combination Chemotherapy)
12/2013
1Radiotherapy
12/2013
1Thymectomy
12/2013
1Peripheral Blood Stem Cell Transplantation (Peripheral Stem Cell Transplantation)
12/2002